Hi There , 
I learned from <www.bioperl.org/wiki/Installing_Bioperl_for_Unix>
I need <make. For Mac OS X, this requires installing the Xcode Developer Tools.>
unfortunatelly ADS offers only new version of xcode not supported on macosx10.4 
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where could i possibly download obsolete xcode who works with osx10.4
best 
WK