[EMBOSS] gap penalties for water
Guy Bottu
gbottu at ben.vub.ac.be
Thu Dec 4 18:58:28 UTC 2003
Well, there are two ways to compute a penalty for a gap of n positions :
<gap opening penalty> + (n - 1) * <gap extension penalty>
<gap penalty> + n * <gap length penalty>
The first way is used by EMBOSS and BLAST
The second way is used by GCG, Staden and CLUSTAL
fastA used for a long time the first way, but Prof. pearson decided
recently to shift to the second
The two methods are basically equivalent (it depends on which values you
choose) and you can discuss at infinitam and ad nauseam which is best.
Regards,
Guy Bottu
Belgian EMBnet Node
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