[Bioperl-l] trouble with Boulder::Genbank module
Lincoln Stein
lstein@cshl.org
Mon, 17 Dec 2001 13:05:59 -0500
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Hi Josiah,
I can't reproduce your problem. The script works as is (with a few
modifications in order to support "use strict".
You did not say what version of Boulder::GenBank you are using, so I am
enclosing the latest version for you to test with (with apologies to others
on the mailing list).
Although I don't recommend Boulder::Genbank for most purposes, it does have
some features that Bio::DB::GenBank still doesn't offer:
1) uses Batch Entrez
2) gets around Batch Entrez's 50K download limits by queueing up
requests intelligently. You can download entire
databases
3) accepts Entrez query language statements
Lincoln
On Saturday 15 December 2001 18:04, Osborne, Brian wrote:
> Josiah,
>
> There's an alternative method to querying Genbank, it uses the
> Bio::DB::GenBank module. From the module's documentation :
>
> $gb = new Bio::DB::GenBank;
>
> $seq = $gb->get_Seq_by_id('MUSIGHBA1'); # Unique ID
>
> # or ...
>
> $seq = $gb->get_Seq_by_acc('J00522'); # Accession Number
>
> # or ... best when downloading very large files, prevents
> # keeping all of the file in memory
>
> # also don't want features, just sequence so let's save bandwith
> # and request Fasta sequence
>
> $gb = new Bio::DB::GenBank(-retrievaltype => 'tempfile' ,
> -format => 'Fasta');
> my $seqio = $gb->get_Stream_by_acc(['AC013798', 'AC021953'] );
> while( my $clone = $seqio->next_seq ) {
> print "cloneid is ", $clone->
> }
>
> See http://www.bioperl.org/Core/POD/Bio/DB/GenBank.html for a more detailed
> description. However, I don't see that this module enables a query by
> species in a straightforward way, as in your own example. Rather, the
> module documentation says :
>
> Batch Entrez support will likely be supported in a future version of
> DB::GenBank.
>
>
> Brian O.
>
>
> -----Original Message-----
> From: Josiah Altschuler
> To: 'bioperl-l@bioperl.org'
> Sent: 12/15/01 2:42 PM
> Subject: [Bioperl-l] trouble with Boulder::Genbank module
>
> Hi. I'm running ActivePerl 5.6 on Windows 2000. I installed the
> Boulder
> module from CPAN and I'm trying to access Genbank using
> Boulder::Genbank.
> I'm able to retrieve the correct entries by query, but it keeps
> retrieving
> them over and over in an infinite loop. I figure by showing my code
> below,
> someone can see where I'm making a mistake?
> Also, I couldn't find anything in bioperl that would allow me to search
> Genbank by query like I'm doing here with Boulder::Genbank. Is this
> correct?
> Anyways, thanks for any help you can give me.
>
> Here is the code,
> Josiah
>
>
> use Boulder::Genbank;
>
> $a = "courant_nrdb.txt"; #output file for query results
> $query = 'Neolamprologus brichardi[Organism]';
> $gb = Boulder::Genbank->newFh(-accessor => 'Entrez',
> -query => $query,
> -db => 'n');
>
> open(OUT, ">$a") || die "cannot create a: $!";
>
> while ($data = <$gb>)
> {
> print "entry retrieved\n"; #Telling me it got an entry (It's
> repeating infinitely)
> $gi = $data->Nid;
> $gi =~ s/\D//g; #Get rid of first letter in GI entry
>
> #Now print the entry in FASTA format
> print OUT ">gi|$gi|gb|";
> print OUT $data->Version;
> print OUT "|";
> print OUT $data->Accession;
> print OUT " ";
> print OUT $data->Definition;
> print OUT "\n";
> print OUT $data->Sequence;
> print OUT "\n";
> }
> close OUT;
> _______________________________________________
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--
========================================================================
Lincoln D. Stein Cold Spring Harbor Laboratory
lstein@cshl.org Cold Spring Harbor, NY
========================================================================
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