There have been at least a coupl eof posts recently about users having problems installing bioperl 1.4 using the PPM GUI shipped with ActivePerl 5.8.8.819. I think this is because the Bioperl 1.4 ppd is built for PPM3 and not PPM4. Would it make sense to update the Bioperl 1.4 PPD since it is the official "stable" release? Nath