[Biojava-l] Isoelectirc point

[Matthew Pocock]

Blum, Bruce wrote:
> Hello,
> 
> Does biojava have any class which can calculate a protein's isoelectric
> point if given a sequence?
> 
> Thank you,
> 
> Bruce Blum
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> 

Hi Bruce,

Sory. There isn't currently anything thad does what you need We have a 
package org.biojava.bio.proteomics with classes Digest, MassCalc and 
Protease. It looks like the ideal place to put an IsoelectricCalc class, 
or perhaps a single class for calculating a global property of an entire 
protein sequence which can be parameterised by mass tables, isoelectric 
points, or whatever else.

Among the news groups there are a consitent stream of requests for 
isoelectric point calculators. Would anyone like to volunteere 
code/tables that do the job?

Matthew

ps On a sort of related point, to make these things work we need a 
framework for representing residue modifications e.g. phosphorylation, 
methylation